del Buey María A, Cristóbal José A, Ascaso Francisco J, Lavilla Laura, Lanchares Elena
Department of Ophthalmology, University Clinic Hospital, Zaragoza, Spain.
Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3199-202. doi: 10.1167/iovs.08-3312. Epub 2009 Feb 28.
To investigate the effects of Fuchs' corneal dystrophy (FCD) on corneal biomechanical properties and the results of IOP readings in relation to changes in corneal hysteresis (CH) and central corneal thickness (CCT).
Corneal biomechanical properties, including CH, corneal resistance factor (CRF), and CCT, were measured with the ocular response analyzer (ORA) in 11 eyes of 11 patients with clinically confirmed FCD and 12 eyes of 12 healthy subjects. The ORA was also used to determine the values of intraocular pressure (IOP(g)) and corneal compensated IOP (IOP(cc)). Goldmann applanation tonometry (GAT) was also measured.
CH measured 10.3 +/- 1.6 mm Hg (range, 8.7-13.8) in normal eyes and 6.9 +/- 1.8 mm Hg (range, 4.6-11.7) in FCD eyes (P = 0.001). CRF in the normal and FCD eyes was 10.5 +/- 1.5 mm Hg (range, 8.5-13.3) and 8.1 +/- 1.9 (range, 4.5-11.2), respectively (P = 0.005). CCT was higher in FCD eyes (606 +/- 20 microm; range, 578-635) than in normal eyes (538.4 +/- 24.9 microm; range, 495-575; P = 0.0001). IOP(g) was 16.2 +/- 2.2 mm Hg (range, 13.5-18.7) in control eyes compared with 17.6 +/- 2.7 mm Hg (range, 12.8-18.6) in FCD eyes (P = 0.201). However, IOP(cc) in the FCD group (21.8 +/- 4.6 mm Hg; range, 12.8-29.0) was higher than in the control group (16.5 +/- 3.4 mm Hg; range, 11.9-23.9; P = 0.006). GAT in the normal and FCD eyes was 16.7 +/- 2.1 mm Hg (range, 12.8-18.6) and 16.9 +/- 2.3 mm Hg (range, 13.1-19.0), respectively (P = 0.205).
FCD led to a change of corneal biomechanical properties. CH and CRF were significantly lower in FCD eyes than in normal eyes. IOP(cc) was significantly higher in FCD eyes than in control eyes. These values may be useful in addition to CCT when assessing corneal rigidity. Thus, FCD may cause an underestimation error in IOP measurement.
研究富克斯角膜营养不良（FCD）对角膜生物力学特性的影响，以及与角膜滞后（CH）和中央角膜厚度（CCT）变化相关的眼压测量结果。
使用眼反应分析仪（ORA）测量11例临床确诊FCD患者的11只眼和12名健康受试者的12只眼的角膜生物力学特性，包括CH、角膜阻力因子（CRF）和CCT。ORA还用于确定眼内压（IOP(g)）和角膜补偿眼压（IOP(cc)）的值。同时测量Goldmann压平眼压计（GAT）。
正常眼的CH为10.3±1.6mmHg（范围8.7 - 13.8），FCD眼为6.9±1.8mmHg（范围4.6 - 11.7）（P = 0.001）。正常眼和FCD眼的CRF分别为10.5±1.5mmHg（范围8.5 - 13.3）和8.1±1.9（范围4.5 - 11.2）（P = 0.005）。FCD眼的CCT更高（606±20μm；范围578 - 635），高于正常眼（538.4±24.9μm；范围495 - 575；P = 0.0001）。对照组眼的IOP(g)为16.2±2.2mmHg（范围13.5 - 18.7），FCD眼为17.6±2.7mmHg（范围12.8 - 18.6）（P = 0.201）。然而，FCD组的IOP(cc)（21.8±4.6mmHg；范围12.8 - 29.0）高于对照组（16.5±3.4mmHg；范围11.9 - 23.9；P = 0.006）。正常眼和FCD眼的GAT分别为16.7±2.1mmHg（范围12.8 - 18.6）和16.9±2.3mmHg（范围13.1 - 19.0）（P = 0.205）。
FCD导致角膜生物力学特性改变。FCD眼的CH和CRF显著低于正常眼。FCD眼的IOP(cc)显著高于对照组眼。在评估角膜硬度时，这些值除CCT外可能也有用。因此，FCD可能导致眼压测量的低估误差。
