Neri Isabella, Monari Francesca, Valensise Herbert, Vasapollo Barbara, Facchinetti Fabio, Volpe Annibale
Mother-Infant Department, University of Modena and Reggio Emilia, Modena, Italy.
Am J Perinatol. 2009 Apr;26(4):259-63. doi: 10.1055/s-0028-1103153. Epub 2008 Nov 19.
We compared the effects of ritodrine and atosiban treatments on fetal cardiovascular behavior by computerized nonstress test (c-NST) analysis. Women diagnosed with preterm labor were randomized to receive either atosiban or ritodrine. A c-NST was performed at least 12 hours after the last corticosteroid administration. Differences in fetal cardiovascular behavior were evident when treatment was given before 30 weeks' gestation. Ritodrine induced higher fetal heart rates, lower long-term variation values, and lower low:high-frequency ratios compared with atosiban. Atosiban induced higher gestational ages at delivery and higher birth weights than ritodrine. The mean Apgar scores were similar for atosiban and ritodrine groups at 1 and 5 minutes. No 5-minute Apgar score was < 7. With respect with atosiban, ritodrine treatment induces tachycardia and a lower variability of fetal heart rate. Such changes could be erroneously interpreted as signal of fetal distress, namely at lower gestational age.
我们通过计算机化无应激试验（c-NST）分析比较了利托君和阿托西班治疗对胎儿心血管行为的影响。被诊断为早产的女性被随机分配接受阿托西班或利托君治疗。在最后一次使用皮质类固醇至少12小时后进行c-NST。当在妊娠30周前进行治疗时，胎儿心血管行为的差异很明显。与阿托西班相比，利托君可导致更高的胎儿心率、更低的长期变异值以及更低的低频：高频比值。阿托西班组的分娩孕周和出生体重均高于利托君组。阿托西班组和利托君组在1分钟和5分钟时的平均阿氏评分相似。5分钟时的阿氏评分均不低于7分。与阿托西班相比，利托君治疗会导致心动过速和胎儿心率变异性降低。这些变化可能会被错误地解释为胎儿窘迫的信号，尤其是在孕周较小的时候。
