Ryoo Sung Weon, Shin Sonya, Shim Myung-shup, Park Yoon-Sung, Lew Woo Jin, Park Sue-Nie, Park Young Kil, Kang Seongman
Department of Microbiology, Korean Institute of Tuberculosis, Seoul, Korea.
J Clin Lab Anal. 2008;22(6):415-20. doi: 10.1002/jcla.20278.
In Korea, the prevalence of nontuberculous mycobacterial (NTM) pulmonary disease has risen, observed primarily in immunocompetent patients with or without preexisting lung disease. The purpose of this study was to determine the frequency of various species of NTM isolates from respiratory specimens in a single institution over a 14-year period in Korea. All samples referred to our reference laboratory over a 14-year period in Korea were analyzed. From 1993 to 2000 our laboratory used conventional NTM identification methods, and from 2001 we adapted PCR-restriction fragment length polymorphism analysis(PRA). A total of 17,915 isolates were collected from 1993 to 2006. The most frequently isolated organisms were M. avium complex (n=11,705, 65%), M. abscessus (n=2,076, 11.59%), M. fortuitum complex (n=1,279, 7.14%). M. chelonae complex (n=1,134, 6.33%), M. kansasii (n=762, 4.25%), M. szulgai (n=139, 0.78%), M. celatum (n=87, 0.49%), M. scrofulaceum (n=18, 0.10%) and M. marium (n=11, 0.06%).
在韩国，非结核分枝杆菌（NTM）肺病的患病率有所上升，主要见于有或无既往肺部疾病的免疫功能正常患者。本研究的目的是确定在韩国一家机构14年期间从呼吸道标本中分离出的各种NTM菌株的频率。对韩国一家参考实验室在14年期间收到的所有样本进行了分析。1993年至2000年，我们实验室使用传统的NTM鉴定方法，2001年起采用聚合酶链反应-限制性片段长度多态性分析（PRA）。1993年至2006年共收集到17915株菌株。最常分离出的菌株为鸟分枝杆菌复合群（n = 11705，65%）、脓肿分枝杆菌（n = 2076，11.59%）、偶发分枝杆菌复合群（n = 1279，7.14%）、龟分枝杆菌复合群（n = 1134，6.33%）、堪萨斯分枝杆菌（n = 762，4.25%）、斯氏分枝杆菌（n = 139，0.78%）、塞拉分枝杆菌（n = 87，0.49%）、瘰疬分枝杆菌（n = 18，0.10%）和海洋分枝杆菌（n = 11，0.06%）。
