Ahn Kwangjin, Kim Young Keun, Hwang Gyu Yel, Cho Hyunmi, Uh Young
Department of Public Health Inspection, Armed Forces Medical Research Institute, Daejeon, Korea.
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Yonsei Med J. 2021 Oct;62(10):903-910. doi: 10.3349/ymj.2021.62.10.903.
Despite decreased prevalence of tuberculosis, the incidence of the diseases associated with nontuberculous mycobacteria (NTM) has been increasing in South Korea and around the world. The present retrospective study was conducted to determine longitudinal changes in the epidemiology and distribution of NTM over 13 years at a tertiary care hospital in Korea.
We retrospectively analyzed data on species over 13 years (January 2007 to December 2019) by utilizing the laboratory information system. species were identified using biochemical tests and PCR-restriction fragment length polymorphism and Mycobacteria GenoBlot assays.
After excluding duplicates from the initial pool of 17996 mycobacterial isolates, 7674 strains were analyzed and 2984 (38.9%) NTM were isolated. The proportion of NTM continuously increased over the 13-year period, from 17.0% in 2007 to 57.5% in 2019. Among the NTM isolates, the most common species were (50.6%), (18.3%), complex (4.9%), (4.5%), (3.3%), (1.1%), (1.0%), and (0.9%). In patients over the age of 70 years, the proportion of NTM among the isolates increased from 26.6% in 2007 to 62.0% in 2019, and that of isolates among the NTM increased from 13.9% (11/79) in 2007 to 37.4% (175/468) in 2019.
The number of NTM isolates continuously increased over the study period, and the increase in the proportion of in patients aged over 70 years was notable.
尽管结核病患病率有所下降，但韩国及全球与非结核分枝杆菌（NTM）相关疾病的发病率一直在上升。本回顾性研究旨在确定韩国一家三级医院13年间NTM流行病学和分布的纵向变化。
我们利用实验室信息系统回顾性分析了13年（2007年1月至2019年12月）间的菌种数据。通过生化试验、PCR-限制性片段长度多态性分析和分枝杆菌基因印迹分析鉴定菌种。
从最初的17996株分枝杆菌分离株中排除重复菌株后，对7674株菌株进行了分析，分离出2984株（38.9%）NTM。在13年期间，NTM的比例持续上升，从2007年的17.0%升至2019年的57.5%。在NTM分离株中，最常见的菌种是（50.6%）、（18.3%）、复合群（4.9%）、（4.5%）、（3.3%）、（1.1%）、（1.0%）和（0.9%）。在70岁以上的患者中，分离株中NTM的比例从2007年的26.6%升至2019年的62.0%，NTM中分离株的比例从2007年的13.9%（11/79）升至2019年的37.4%（175/468）。
在研究期间，NTM分离株数量持续增加，70岁以上患者中分离株比例的增加尤为显著。
