Aisa M L, Omenaca M, Bergua C, Garcia-Moya J B
Infection. 1982;10 Suppl 3:S244-8. doi: 10.1007/BF01640682.
We studied the behaviour of 56 clinical isolates of Pseudomonas aeruginosa strains against the following beta-lactam antibiotics: cefotaxime, cefoperazone, cefsulodin, lamoxactam, Ro 13-9904, azlocillin, mezlocillin and ticarcillin. Twenty-six strains were resistant to gentamicin and 30 to gentamicin and/or carbenicillin. The MICs were measured by the serial dilution test on solid agar. Cefsulodin was the most active cephalosporin against carbenicillin-resistant strains (MIC greater than or equal to 128 mg/l); it inhibited 56.6% of these strains at a concentration of 8 mg/l. Azlocillin was the most active penicillin, inhibiting 79.96% of the same strains at a concentration of 64 mg/l. Cefsulodin was the most active cephalosporin against the gentamicin-resistant group of Pseudomonas aeruginosa strains (MIC greater than or equal to 8 mg/l) which were sensitive to carbenicillin (MIC less than or equal to 64 mg/l). It inhibited 100% of the strains at a concentration of 4 mg/l. All of the penicillins studied inhibited all of the strains in this group. The required concentrations were the following: 16 mg/l for azlocillin, 32 mg/l for mezlocillin and 64 mg/l for ticarcillin.
我们研究了56株铜绿假单胞菌临床分离株对以下β-内酰胺类抗生素的耐药情况：头孢噻肟、头孢哌酮、头孢磺啶、拉氧头孢、Ro 13-9904、阿洛西林、美洛西林和替卡西林。26株对庆大霉素耐药，30株对庆大霉素和/或羧苄西林耐药。通过固体琼脂上的连续稀释试验测定最低抑菌浓度（MIC）。头孢磺啶是对羧苄西林耐药菌株最有效的头孢菌素（MIC大于或等于128mg/L）；在浓度为8mg/L时，它能抑制56.6%的此类菌株。阿洛西林是最有效的青霉素，在浓度为64mg/L时能抑制79.96%的相同菌株。头孢磺啶是对庆大霉素耐药但对羧苄西林敏感（MIC小于或等于64mg/L）的铜绿假单胞菌菌株组最有效的头孢菌素。在浓度为4mg/L时，它能抑制100%的菌株。所有研究的青霉素均能抑制该组中的所有菌株。所需浓度如下：阿洛西林为16mg/L，美洛西林为32mg/L，替卡西林为64mg/L。
