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通过黏附分子ICAM - 1和VCAM - 1的表达区分寻常型银屑病的皮损皮肤和非皮损皮肤。

The distinction between lesional and non-lesional skin in psoriasis vulgaris through expression of adhesion molecules ICAM-1 and VCAM-1.

作者信息

Cabrijan Leo, Batinac Tanja, Lenkovic Maja, Gruber Franjo

机构信息

Department of Dermatovenerology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.

出版信息

Med Hypotheses. 2009 Mar;72(3):327-9. doi: 10.1016/j.mehy.2008.06.049. Epub 2008 Nov 20.

DOI:10.1016/j.mehy.2008.06.049
PMID:19022587
Abstract

Psoriasis vulgaris [pv] is a systemic inflammatory skin disease affecting 2-4% population. It is well known that pv affects some parts of the skin and also whole skin as in erythrodermic form. We still do not know why in pv some parts of the skin are affected and others are not. In our hypothesis we assumed that the whole skin is in <> position and non-lesional skin could become in every moment lesional. According to our hypothesis and also other author's research, high expression of adhesion molecules ICAM-1 and VCAM-1 in lesional as well as non-lesional skin in pv, supports this hypothesis, suggesting a significance of these molecules in pathogenesis of pv. Our hypothesis could be proved by immunohistochemical stain of ICAM-1 and VCAM-1 in lesional and non-lesional skin of pv patient in comparison with healthy skin.

摘要

寻常型银屑病（PV）是一种影响2%-4%人群的全身性炎症性皮肤病。众所周知，PV会影响皮肤的某些部位，也会像红皮病型那样影响整个皮肤。我们仍然不知道为什么在PV中皮肤的某些部位会受到影响而其他部位不会。在我们的假设中，我们假定整个皮肤处于“待命”状态，非皮损部位的皮肤随时可能变成皮损部位。根据我们的假设以及其他作者的研究，PV皮损和非皮损皮肤中黏附分子ICAM-1和VCAM-1的高表达支持了这一假设，表明这些分子在PV发病机制中具有重要意义。通过对PV患者皮损和非皮损皮肤与健康皮肤进行ICAM-1和VCAM-1的免疫组化染色，我们的假设可以得到证实。

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