Moynagh Paul N
Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
Trends Immunol. 2009 Jan;30(1):33-42. doi: 10.1016/j.it.2008.10.001. Epub 2008 Nov 18.
This review highlights the emerging roles of the Pellino family of E3 ubiquitin ligases as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. The functional importance of the Pellino family as RING-like-domain-containing proteins with intrinsic ubiquitin E3 ligase activity that can catalyse polyubiquitylation of the key TLR signalling molecule IRAK1 is discussed in detail. The importance of Pellino proteins as novel targets for mediating negative regulation of TLR signalling is also explored. This new knowledge and understanding of Pellino biology begins to fill some long-standing voids in our understanding of TLR signalling.
本综述强调了E3泛素连接酶Pellino家族作为Toll样受体（TLR）信号通路中上游介质的新作用，该通路可导致丝裂原活化蛋白激酶（MAP激酶）和转录因子的激活。文中详细讨论了Pellino家族作为具有内在泛素E3连接酶活性的含类RING结构域蛋白的功能重要性，这类蛋白可催化关键TLR信号分子白细胞介素-1受体相关激酶1（IRAK1）的多聚泛素化。同时也探讨了Pellino蛋白作为介导TLR信号负调控新靶点的重要性。对Pellino生物学的这一新认识开始填补我们在理解TLR信号方面一些长期存在的空白。
