Marine College, Shandong University, Weihai, China.
School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Front Immunol. 2022 Feb 7;13:728794. doi: 10.3389/fimmu.2022.728794. eCollection 2022.
The Pellino family is a novel and well-conserved E3 ubiquitin ligase family and consists of Pellino1, Pellino2, and Pellino3. Each family member exhibits a highly conserved structure providing ubiquitin ligase activity without abrogating cell and structure-specific function. In this review, we mainly summarized the crucial roles of the Pellino family in pattern recognition receptor-related signaling pathways: IL-1R signaling, Toll-like signaling, NOD-like signaling, T-cell and B-cell signaling, and cell death-related TNFR signaling. We also summarized the current information of the Pellino family in tumorigenesis, microRNAs, and other phenotypes. Finally, we discussed the outstanding questions of the Pellino family in immunity.
佩利诺家族是一个新颖且高度保守的 E3 泛素连接酶家族，包括 Pellino1、Pellino2 和 Pellino3。每个家族成员都具有高度保守的结构，提供泛素连接酶活性，而不会破坏细胞和结构特异性功能。在这篇综述中，我们主要总结了佩利诺家族在模式识别受体相关信号通路中的关键作用：IL-1R 信号、 Toll 样信号、NOD 样信号、T 细胞和 B 细胞信号以及细胞死亡相关的 TNFR 信号。我们还总结了佩利诺家族在肿瘤发生、microRNAs 和其他表型中的最新信息。最后，我们讨论了佩利诺家族在免疫方面的突出问题。
