Ling P R, Istfan N W, Lopes S M, Babayan V K, Blackburn G L, Bistrian B R
Cancer Research Institute, New England Deaconess Hospital, Boston, MA 02215.
Am J Clin Nutr. 1991 May;53(5):1177-84. doi: 10.1093/ajcn/53.5.1177.
The effects of structured lipid composed of fish oil and medium-chain triglycerides (Fish/MCT) on tumor and the host metabolism was compared with conventional long-chain triglycerides (LCTs) in Yoshida-sarcoma-bearing rats receiving TPN for 3 d. The two parenterally fed groups were divided into two treatments, saline or tumor necrosis factor (TNF), given intravenously at 20 micrograms/kg body wt. Changes in tumor volume, body weight, urinary nitrogen, whole-body and tissue protein kinetics, and fatty acid composition were measured. The study revealed that Fish/MCT feeding inhibited tumor growth, which could be attributed to decreased tumor protein synthesis. Body weight and nitrogen were better maintained by Fish/MCT feeding. In addition, the effects of Fish/MCT on tumor growth were synergistic with TNF treatment. The results demonstrate that dietary fat composition can influence fatty acid compositions of tumor tissue as well as tumor protein kinetics after a short period of TPN feeding.
在接受全胃肠外营养（TPN）3天的吉田肉瘤大鼠中，将由鱼油和中链甘油三酯组成的结构化脂质（鱼/中链甘油三酯，Fish/MCT）对肿瘤和宿主代谢的影响与传统长链甘油三酯（LCTs）进行了比较。两个经肠外喂养的组被分为两种处理，即静脉注射20微克/千克体重的生理盐水或肿瘤坏死因子（TNF）。测量了肿瘤体积、体重、尿氮、全身和组织蛋白质动力学以及脂肪酸组成的变化。研究表明，喂养Fish/MCT可抑制肿瘤生长，这可能归因于肿瘤蛋白质合成减少。喂养Fish/MCT能更好地维持体重和氮平衡。此外，Fish/MCT对肿瘤生长的影响与TNF治疗具有协同作用。结果表明，在短期TPN喂养后，饮食脂肪组成可影响肿瘤组织的脂肪酸组成以及肿瘤蛋白质动力学。
