Wolters U, Keller H W, Becker R, Stickeler P, Dahlmeyer M, Müller J M
Department of Surgery, Cologne University, FRG.
Eur Surg Res. 1994;26(5):288-97. doi: 10.1159/000129348.
The aim of parenteral nutrition in tumour patients is to offer an alternative nutritional support to the patient without accelerating the growth of the tumour. For this purpose we fed a total of 100 rats, divided into five groups of 20 animals each (10 with and 10 without tumours), for a total period of 15 days with various nutritional regimes. Group 1 received glucose, group 2 long-chain triglycerides, group 3 medium-chain triglycerides (MCT), group 4 omega-3 fatty acids, and group 5 an oral diet. On the 10th day the Yoshida sarcoma in its ascites form was implanted into the tumour-bearing rats. In animals receiving MCT or omega-3 fatty acids tumour growth was considerably smaller than in the other groups (group 1 vs. groups 3 and 4; p < 0.05). Unfavourable effects of the administration of these fatty acids on the general condition of the animals were not observed [muscle nitrogen content (mg/kg body weight): MCT = 82.3, omega-3 fatty acids = 65.25]. The impulse cytophotometric measurements did not demonstrate any influence on the pattern of cell division (p > 0.05). We think that modulation of the immune system by feeding with MCT or omega-3 fatty acids was responsible for the reduced tumour growth in relation to the other groups. The extrapolation of these results to the clinical situation, however, may not be possible.
肿瘤患者肠外营养的目的是为患者提供一种替代营养支持，同时又不加速肿瘤生长。为此，我们总共喂养了100只大鼠，将其分为五组，每组20只动物（10只患有肿瘤，10只未患肿瘤），采用不同的营养方案，为期15天。第1组给予葡萄糖，第2组给予长链甘油三酯，第3组给予中链甘油三酯（MCT），第4组给予ω-3脂肪酸，第5组给予口服饮食。在第10天，将腹水型吉田肉瘤植入患有肿瘤的大鼠体内。接受MCT或ω-3脂肪酸的动物肿瘤生长明显小于其他组（第1组与第3组和第4组相比；p<0.05）。未观察到给予这些脂肪酸对动物一般状况有不利影响[肌肉氮含量（mg/kg体重）：MCT = 82.3，ω-3脂肪酸 = 65.25]。脉冲细胞光度测量未显示对细胞分裂模式有任何影响（p>0.05）。我们认为，与其他组相比，通过给予MCT或ω-3脂肪酸调节免疫系统是肿瘤生长减少的原因。然而，将这些结果外推至临床情况可能并不可行。
