The mechanism of cytotoxic action of acetylcysteine in combination with vitamin B12b.

作者信息

Faskhutdinova A A, Akatov V S, Solov'eva M E, Solov'ev V S, Chailakhyan L M

机构信息

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, pr Nauki, Pushchino, Moscow oblast 142292, Russia.

出版信息

Dokl Biol Sci. 2008 Sep-Oct;422:366-8. doi: 10.1134/s001249660805027x.

DOI:10.1134/s001249660805027x

PMID:19024698

Abstract

摘要

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本文引用的文献

Vitamin B12b enhances the cytotoxicity of dithiothreitol.

Free Radic Biol Med. 2008 May 15;44(10):1846-56. doi: 10.1016/j.freeradbiomed.2008.02.002. Epub 2008 Feb 20.

Vitamin B12b increases the cytotoxicity of short-time exposure to ascorbic acid, inducing oxidative burst and iron-dependent DNA damage.

Eur J Pharmacol. 2007 Jul 2;566(1-3):206-14. doi: 10.1016/j.ejphar.2007.03.035. Epub 2007 Mar 30.

[Prooxidant and cytotoxic action of N-acetylcysteine and glutathione combined with vitamin Bl2b].

Tsitologiia. 2007;49(1):70-8.

Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine.

Int J Geriatr Psychiatry. 2001 Jun;16(6):609-14. doi: 10.1002/gps.388.

Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture.

Biochem J. 2001 Jun 1;356(Pt 2):549-55. doi: 10.1042/0264-6021:3560549.

SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay).

Free Radic Biol Med. 2001 Mar 15;30(6):679-85. doi: 10.1016/s0891-5849(00)00511-6.

Coumarin-3-carboxylic acid as a detector for hydroxyl radicals generated chemically and by gamma radiation.

Radiat Res. 1997 Dec;148(6):580-91.

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