Ponnusamy K, Mohan M, Nagaraja H S
Department of Human Biology, International Medical University, Kuala Lumpur, Malaysia.
Med J Malaysia. 2008 Jul;63 Suppl A:102.
Lead (Pb) is a neurotoxic heavy metal and children in the developmental stage are particularly susceptible to toxic effects of lead exposure. The brain is the key organ involved in interpreting and responding to potential stressors. Epidemiological investigations have established the relationship between chronic lead exposure and cognitive impairments in young children. Excessive production of radical species plays an important role in neuronal pathology resulting from excitotoxic insults, therefore one plausible neuroprotective mechanism of bioflavonoids is partly relevant to their metal chelating and antioxidant properties. Centella asiatica (CA) is a tropical medicinal plant enriched with bioflavonoids and triterpenes and selenium, reported to rejuvenate the cells and promote physical and mental health. Bioflavonoids are claimed to be exert antimutagenic, neurotrophic and xenobiotics ameliorating and membrane molecular stabilizing effects. The objective of the present work is to study the protective antioxidant effect of pretreatment of CA extract (CAE) on lead acetate induced changes in oxidative biomarkers in the central nervous system (CNS) of mice.
铅（Pb）是一种具有神经毒性的重金属，处于发育阶段的儿童尤其容易受到铅暴露毒性影响。大脑是参与解读和应对潜在应激源的关键器官。流行病学调查已证实幼儿慢性铅暴露与认知障碍之间的关联。自由基的过度产生在兴奋性毒性损伤导致的神经元病变中起重要作用，因此生物类黄酮一种可能的神经保护机制部分与其金属螯合和抗氧化特性有关。积雪草是一种富含生物类黄酮、三萜类化合物和硒的热带药用植物，据报道具有细胞再生及促进身心健康的作用。生物类黄酮据称具有抗诱变、神经营养、改善外源性物质及稳定膜分子的作用。本研究的目的是探讨积雪草提取物（CAE）预处理对醋酸铅诱导的小鼠中枢神经系统（CNS）氧化生物标志物变化的抗氧化保护作用。
