Ling W Y, Marsh J M, LeMaire W J
J Clin Endocrinol Metab. 1977 Mar;44(3):514-9. doi: 10.1210/jcem-44-3-514.
Adenosine-3',5'-monophosphate (cyclic AMP) concentration was measured in plasma from nonpregnant women; women in the 7-41 weeks of normal pregnancy; during labor; and 5-7 h postpartum. The cyclic AMP levels in the course of normal pregnancy showed an initial peak volume at 14 weeks. After falling to nonpregnant level at 18 weeks, it began to rise steadily and reached a second peak at 34 weeks. A gradual decline was then followed until labor. The postpartum plasma concentration was significantly lower than the nonpregnant level. A similar pattern was found in serial studies in 4 women of normal pregnancy. Sequential cyclic AMP measurement in 5 hypertensive pregnancies showed a markedly elevated level during 16-26 weeks, but became comparable to normal pregnancy values thereafter. In the only preeclamptic patient studied, cyclic AMP was elevated in the 16-27th weeks although no clinical symptom was found until the 31st week. The study showed that the plasma cyclic AMP level in normal pregnancy becomes elevated above nonpregnant level at the end of the first and during the third trimesters. However, this profile appeared to be altered in pregnancies complicated by hypertension.
对非孕期女性、孕期7至41周的女性、分娩期间以及产后5至7小时的女性血浆中的3',5'-环磷酸腺苷（环磷腺苷）浓度进行了测定。正常孕期过程中的环磷腺苷水平在孕14周时出现首个峰值。在孕18周降至非孕期水平后，又开始稳步上升，并在孕34周时达到第二个峰值。随后逐渐下降直至分娩。产后血浆浓度显著低于非孕期水平。对4名正常孕期女性的系列研究也发现了类似模式。对5例高血压妊娠的连续环磷腺苷测量显示，在孕16至26周期间水平显著升高，但此后与正常孕期值相当。在唯一研究的先兆子痫患者中，孕16至27周期间环磷腺苷升高，尽管直到孕31周才出现临床症状。该研究表明，正常孕期血浆环磷腺苷水平在孕早期末和孕晚期会高于非孕期水平。然而，在并发高血压的妊娠中，这种情况似乎有所改变。
