对采自越南的鸦胆子叶细胞毒性成分进行生物活性导向的分离。
Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam.
作者信息
Pan Li, Chin Young-Won, Chai Hee-Byung, Ninh Tran Ngoc, Soejarto Djaja Djendoel, Kinghorn A Douglas
机构信息
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA.
出版信息
Bioorg Med Chem. 2009 Mar 15;17(6):2219-24. doi: 10.1016/j.bmc.2008.10.076. Epub 2008 Nov 5.
Abstract
Five new triterpenoids (1-5), together with two known quassinoids, bruceantin (6) and bruceine A (7), and a known flavonolignan, (-)-hydnocarpin (8), were isolated from the chloroform-soluble subfraction of a methanol extract of the combined twigs, leaves, and inflorescence of Brucea javanica collected in Vietnam. The structures of the new compounds 1-5 were established on the basis of spectroscopic methods. All isolates were evaluated for cytotoxicity against a small panel of human cancer cell lines. Quassinoids 6 and 7 were found to be highly active against these cell lines. (-)-Hydnocarpin (8) showed a potentiating effect when combined with both 6 and 7, during cytotoxicity testing using the MCF-7 human breast cancer cell line.
摘要
从越南采集的鸦胆子的嫩枝、叶子和花序的甲醇提取物的氯仿可溶亚组分中，分离出5个新的三萜类化合物（1-5），以及2个已知的苦木素类化合物鸦胆丁（6）和鸦胆因A（7），还有1个已知的黄酮木脂素（-）-氢化葛鸦宁（8）。通过光谱方法确定了新化合物1-5的结构。对所有分离物针对一小批人类癌细胞系进行了细胞毒性评估。发现苦木素类化合物6和7对这些细胞系具有高活性。在使用MCF-7人乳腺癌细胞系进行细胞毒性测试时，（-）-氢化葛鸦宁（8）与6和7联合使用时显示出增效作用。
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