Günther Svenja, Storm Janet, Müller Sylke
Division of Infection & Immunity, Glasgow Biomedical Research Centre, Faculty of Biomedical Life Sciences, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.
Int J Biochem Cell Biol. 2009 Apr;41(4):748-52. doi: 10.1016/j.biocel.2008.10.028. Epub 2008 Nov 5.
Lipoic acid is an essential cofactor of multienzyme complexes that are integral to energy metabolism, amino acid degradation and folate metabolism. In recent years it has been shown that the malaria parasite Plasmodium falciparum possesses organelle-specific pathways that guarantee the lipoylation of their multienzyme complexes which occur in the mitochondrion (LA salvage) and in a plastid-like organelle, the apicoplast (LA biosynthesis). The unique distribution of the lipoylation machineries and the unique metabolic requirements of the parasites present a situation that is potentially exploitable for new ways to improve malaria control.
硫辛酸是多酶复合体的一种必需辅因子，这些多酶复合体对于能量代谢、氨基酸降解和叶酸代谢不可或缺。近年来研究表明，疟原虫恶性疟原虫拥有细胞器特异性途径，可确保其多酶复合体发生硫辛酰化，这些多酶复合体存在于线粒体（硫辛酸挽救途径）和类质体细胞器即顶质体（硫辛酸生物合成途径）中。硫辛酰化机制的独特分布以及疟原虫独特的代谢需求，为改进疟疾控制的新方法提供了潜在的可利用条件。
