变形链球菌生物膜形成过程中淀粉和蔗糖作用的结构与分子基础
Structural and molecular basis of the role of starch and sucrose in Streptococcus mutans biofilm development.
作者信息
Klein M I, Duarte S, Xiao J, Mitra S, Foster T H, Koo H
机构信息
Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, New York 14620, USA.
出版信息
Appl Environ Microbiol. 2009 Feb;75(3):837-41. doi: 10.1128/AEM.01299-08. Epub 2008 Nov 21.
Abstract
The interaction of sucrose and starch with bacterial glucosyltransferases and human salivary amylase may enhance the pathogenic potential of Streptococcus mutans within biofilms by influencing the structural organization of the extracellular matrix and modulating the expression of genes involved in exopolysaccharide synthesis and specific sugar transport and two-component systems.
摘要
蔗糖和淀粉与细菌葡糖基转移酶及人类唾液淀粉酶的相互作用，可能通过影响细胞外基质的结构组织以及调节参与胞外多糖合成、特定糖转运和双组分系统的基因表达，增强变形链球菌在生物膜内的致病潜力。
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