Blockley N P, Jiang L, Gardener A G, Ludman C N, Francis S T, Gowland P A
Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom.
Magn Reson Med. 2008 Dec;60(6):1313-20. doi: 10.1002/mrm.21792.
This study has measured the longitudinal and transverse (T2* relaxivity curves for ProHance (Gadoteridol), Vasovist (Gadofosveset) and deoxyhemoglobin at 1.5, 3.0, and 7.0 Tesla. The plots of R(1) versus both contrast agent and deoxyhemoglobin concentration were linear. The plots of R2* versus deoxyhemoglobin concentration showed a quadratic dependence. R2* versus contrast agent concentration showed a parabolic dependence with a minimum occurring at contrast agent concentrations of approximately 1.5 mM, corresponding to an accessible concentration in vivo. Monte Carlo simulations were performed to support the hypothesis that the minimum results from the susceptibility of the red blood cells being matched to the susceptibility of the plasma. Relaxivity values (s(-1)mM(-1)) for R2* and R1 for all agents and all three field strengths are given.
本研究测量了在1.5、3.0和7.0特斯拉磁场下，普美显（钆特醇）、血管显（钆弗塞特）和脱氧血红蛋白的纵向和横向（T2弛豫率曲线）。R(1)与造影剂及脱氧血红蛋白浓度的关系图呈线性。R2与脱氧血红蛋白浓度的关系图呈二次依赖性。R2与造影剂浓度的关系图呈抛物线依赖性，在造影剂浓度约为1.5 mM时出现最小值，这与体内可达到的浓度相对应。进行了蒙特卡罗模拟，以支持红细胞的磁化率与血浆磁化率相匹配导致最小值这一假设。给出了所有试剂在所有三种场强下的R2和R1弛豫率值（s(-1)mM(-1)）。
