用于基于¹⁹F核磁共振筛选的多氟代L-赖氨酸的改进合成方法。
Improved synthesis of polyfluorinated L-lysine for 19F NMR-based screening.
作者信息
Malgesini Beatrice, Felder Eduard, Mongelli Nicola, Papeo Gianluca
机构信息
Department of Chemistry, BU-Oncology, Nerviano Medical Sciences, Viale Pasteur 10, Nerviano, MI, 20014, Italy.
出版信息
Mol Divers. 2009 Feb;13(1):53-6. doi: 10.1007/s11030-008-9097-5. Epub 2008 Nov 22.
PMID:19031002
Abstract
Polyfluorinated N-alpha-Fmoc-is an element of-Boc-L-lysine represents the best-in-class among a set of polyfluorinated amino acids (PFAs) which are useful tools for (19)F NMR-Based Screening. In this communication, optimized reaction conditions that allowed for the multi-gram preparation of this unnatural amino acid are reported.
摘要
多氟代 N-α-芴甲氧羰基-N-叔丁氧羰基-L-赖氨酸是一组多氟代氨基酸（PFAs）中的最佳代表，这些多氟代氨基酸是基于¹⁹F NMR筛选的有用工具。在本通讯中，报道了可实现该非天然氨基酸多克级制备的优化反应条件。
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