设计和合成新型 19F-氨基酸：一种用于肽研究的有前途的 19F NMR 标记物。
Design and synthesis of novel 19F-amino acid: a promising 19F NMR label for peptide studies.
机构信息
Department of Chemistry, Taras Shevchenko National University of Kyiv , Volodymyrska 64, Kyiv 01601, Ukraine.
出版信息
Org Lett. 2015 Jan 16;17(2):226-9. doi: 10.1021/ol503300m. Epub 2014 Dec 29.
PMID:25545327
Abstract
Novel aliphatic (19)F-substituted amino acid was designed as a (19)F NMR label for peptide studies. The synthesis was performed in 11 steps and 9% overall yield from a commercially available starting material. The key transformation was a decarboxylative fluorination of an aliphatic carboxylic acid with XeF2 in C6F6.
摘要
新型脂肪族（19）F 取代氨基酸被设计为用于研究肽的（19）F NMR 标记物。该合成是从商业上可获得的起始原料出发，经 11 步反应以 9%的总收率完成的。关键转化是在六氟苯中用氙化氟（XeF2）对脂肪族羧酸进行脱羧氟化。
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