Si Chuan-Ling, Deng Xiao-Juan, Liu Zhong, Kim Jin-Kyu, Bae Young-Soo
Tianjin Key Laboratory of Pulp & Paper, College of Material Science and Chemical Engineering, Tianjin University of Science and Technology, Tianjin, China.
J Asian Nat Prod Res. 2008 Nov-Dec;10(11-12):1003-8. doi: 10.1080/10286020802242364.
Four epimeric phenylethanoid glycosides, including a new one, R,S-beta-ethoxy-beta-(3,4-dihydroxyphenyl)-ethyl-O-alpha-L-rhamnopyranosyl(1-->3)-beta-D-(6-O-E-caffeoyl)-glucopyranoside named isoilicifolioside A (1), and three known compounds, ilicifolioside A (2), campneoside II (3), and isocampneoside II (4), were isolated from Paulownia tomentosa var. tomentosa wood. The structures of the four compounds were elucidated by the interpretation of 1D and 2D NMR and MS spectra. This is the first report of the chemical profile of this tree. Compounds 1-4 exhibited excellent anti-complement activity with IC(50) values less than 74 microM, compared with tiliroside (IC(50) = 104 microM) and rosmarinic acid (IC(50) = 182 microM) that were used as positive controls.
从毛泡桐木材中分离得到了4个差向异构的苯乙醇苷类化合物，其中包括1个新化合物，即R，S-β-乙氧基-β-(3,4-二羟基苯基)乙基-O-α-L-鼠李糖基(1→3)-β-D-(6-O-E-咖啡酰基)-葡萄糖苷，命名为异毛泡桐苷A(1)，以及3个已知化合物，毛泡桐苷A(2)、梓醇苷II(3)和异梓醇苷II(4)。通过一维和二维核磁共振谱以及质谱分析确定了这4个化合物的结构。这是关于该树种化学特征的首次报道。与用作阳性对照的椴树苷(IC50 = 104 μM)和迷迭香酸(IC50 = 182 μM)相比，化合物1-4表现出优异的抗补体活性，IC50值小于74 μM。
