生长温度对小鼠体内单核细胞增生李斯特菌菌株毒力的影响：剂量依赖性证据
Effect of growth temperature on virulence of strains of Listeria monocytogenes in the mouse: evidence for a dose dependence.
作者信息
Stephens J C, Roberts I S, Jones D, Andrew P W
机构信息
Department of Microbiology, University of Leicester, UK.
出版信息
J Appl Bacteriol. 1991 Mar;70(3):239-44. doi: 10.1111/j.1365-2672.1991.tb02931.x.
Growth of Listeria monocytogenes at 4 degrees C significantly increased its virulence for mice by the intravenous route and the effect was dose-dependent. Virulence was apparent only at a dose of about or above 10(4) viable listerias. At slightly lower doses of about 10(3), no such effect was observed. Growth at 4 degrees C did not increase the virulence of the strains for mice by oral-gastric challenge when given at doses of approximately 10(10).
单核细胞增生李斯特菌在4℃下生长显著增强了其经静脉途径对小鼠的毒力，且这种效应呈剂量依赖性。仅在约10⁴个活李斯特菌或更高剂量时毒力才明显。在略低剂量约10³时，未观察到这种效应。当以约10¹⁰的剂量经口胃途径给予时，4℃下生长并未增加菌株对小鼠的毒力。
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