Wang Hong-yan, Pan Ya-ping
Department of Periodontology, School of Stomatology, China Medical University, Shenyang 110002, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2008 Jul;43(7):406-9.
To detect the susceptible alleles in generalized aggressive periodontitis patients and healthy controls and to analyze the effect of multi-alleles on the occurrence and development of generalized aggressive periodontitis.
Polymerase chain reaction and cleavage were used for detecting the frequencies of five susceptible genetic polymorphisms in generalized aggressive periodontitis patients and healthy controls. The results were analyzed by Z-score test and mean square analysis.
The frequencies of homozygous for HLA-DRB1* 1501 allele, TNF-A-308 allele II, IL-1B(+3953) allele II, vitamin D receptor allele A, T, estrogen receptor allele X in generalized aggressive periodontitis patients were higher than those in healthy controls. The persons who took more than three susceptible alleles (including three susceptible alleles) had more severe periodontal conditions than the ones who took less than three susceptible alleles (not including three susceptible alleles).
HLA-DRB1 * 1501 allele, TNFA-308 allele II, IL-1B(+3953) allele II, vitamin D receptor allele A, T, estrogen receptor allele X are susceptible alleles in generalized aggressive periodontitis. Carrying more than three susceptible alleles has a great effect on the occurrence and development of generalized aggressive periodontitis.
检测广泛侵袭性牙周炎患者和健康对照者中的易感等位基因，并分析多等位基因对广泛侵袭性牙周炎发生发展的影响。
采用聚合酶链反应和酶切法检测广泛侵袭性牙周炎患者和健康对照者中5种易感基因多态性的频率。结果采用Z检验和均方分析进行分析。
广泛侵袭性牙周炎患者中HLA-DRB1*1501等位基因、TNF-A -308等位基因II、IL-1B(+3953)等位基因II、维生素D受体等位基因A、T、雌激素受体等位基因X的纯合子频率高于健康对照者。携带3个及以上易感等位基因（包括3个易感等位基因）的患者牙周状况比携带少于3个易感等位基因（不包括3个易感等位基因）的患者更严重。
HLA-DRB1*1501等位基因、TNFA -308等位基因II、IL-1B(+3953)等位基因II、维生素D受体等位基因A、T、雌激素受体等位基因X是广泛侵袭性牙周炎的易感等位基因。携带3个以上易感等位基因对广泛侵袭性牙周炎的发生发展有很大影响。
