Keenan R T, Swearingen C J, Yazici Y
NYU Hospital for Joint Disease, New York, USA.
Clin Exp Rheumatol. 2008 Sep-Oct;26(5):814-9.
To determine the patterns and correlation of elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels with outcome measures in rheumatoid arthritis (RA), and compare it to systemic lupus erythematosus (SLE) and osteoarthritis (OA) patients.
Brooklyn Outcomes Arthritis Registry Database (BOARD) was analyzed to determine both first visit and mean values of ESR and CRP, along with disease activity measures in each patient. Data were analyzed with descriptive statistics and correlations.
Among all patients half of all (n=377) ESR results were elevated. In RA patients the proportions of having both ESR and CRP elevated, both within normal levels, and only one elevated and the other normal were similar. For all diagnosis, both ESR and CRP have weak positive correlations with disease activity measures measured at first visits. ESR and CRP have a modest positive correlation with each other across all three disease groups.
In this cohort of RA, SLE and OA patients, ESR and CRP values were modestly correlated with each other and they were weakly correlated with disease activity measures. These data suggest that another look at the role of ESR and CRP as markers of inflammation in RA patients seen in routine care may be in order.
确定类风湿关节炎（RA）患者中红细胞沉降率（ESR）和C反应蛋白（CRP）水平升高的模式及其与预后指标的相关性，并将其与系统性红斑狼疮（SLE）和骨关节炎（OA）患者进行比较。
分析布鲁克林关节炎预后登记数据库（BOARD），以确定每位患者ESR和CRP的首次就诊值及平均值，以及疾病活动指标。采用描述性统计和相关性分析数据。
在所有患者中，一半（n = 377）的ESR结果升高。在RA患者中，ESR和CRP均升高、均在正常水平、仅一项升高而另一项正常的比例相似。对于所有诊断，ESR和CRP与首次就诊时测量的疾病活动指标均呈弱正相关。在所有三个疾病组中，ESR和CRP彼此呈中度正相关。
在该队列RA、SLE和OA患者中，ESR和CRP值彼此中度相关，且与疾病活动指标弱相关。这些数据表明，可能需要重新审视ESR和CRP在常规治疗的RA患者中作为炎症标志物的作用。
