人类前B细胞特异性λ样基因簇位于22q11.2 - 22q12.3区域，在免疫球蛋白Cλ基因座的远端。
The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus.
作者信息
Mattei M G, Fumoux F, Roeckel N, Fougereau M, Schiff C
机构信息
Centre de Génétique de la Timone, Hôpital d'Enfants, Marseille, France.
出版信息
Genomics. 1991 Mar;9(3):544-6. doi: 10.1016/0888-7543(91)90422-b.
The chromosomal location of the lambda-like gene cluster, a gene family selectively expressed in human pre-B cells, was analyzed by in situ hybridization with a probe specific for the lambda-like genes. This cluster mapped in the q11.2-q12.3 region of chromosome 22. The use of Burkitt lymphoma and myelogenous leukemia cell lines with translocations in the 22q11 region led to a refinement in the location according to the following order: cen----BCRL2, VpreB, IgV lambda 1----BCRL4, IgV lambda----IgC lambda----BCR----BCRL3, lambda-like----tel. Unlike those of the mouse system, the pre-B-specific genes VpreB and lambda-like do not belong to the same transcriptional unit.
通过用针对λ样基因的特异性探针进行原位杂交，分析了在人类前B细胞中选择性表达的一个基因家族——λ样基因簇的染色体定位。该基因簇定位于22号染色体的q11.2-q12.3区域。利用在22q11区域发生易位的伯基特淋巴瘤和髓性白血病细胞系，根据以下顺序对其定位进行了细化：着丝粒----BCRL2、VpreB、IgVλ1----BCRL4、IgVλ----IgCλ----BCR----BCRL3、λ样----端粒。与小鼠系统不同，前B细胞特异性基因VpreB和λ样基因不属于同一个转录单位。
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