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λ轻链基因座的染色体定位：Vλ在22q11中靠近Cλ。

Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.

作者信息

Emanuel B S, Cannizzaro L A, Magrath I, Tsujimoto Y, Nowell P C, Croce C M

出版信息

Nucleic Acids Res. 1985 Jan 25;13(2):381-7. doi: 10.1093/nar/13.2.381.

DOI:10.1093/nar/13.2.381
PMID:3923432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC341002/
Abstract

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the C lambda and some V lambda sequences translocate to the 8q+ chromosome whereas some V lambda sequences remain on the 22q-. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that V lambda is proximal to C lambda.

摘要

我们已经证明，具有8;22易位的伯基特淋巴瘤细胞系（PA682）在22q11处的染色体断点中断了λ轻链基因座的可变区。在这些细胞中，所有的Cλ和一些Vλ序列易位到8q +染色体上，而一些Vλ序列仍留在22q - 染色体上。这些结果表明，22号染色体长臂上的λ轻链基因座的方向是Vλ靠近Cλ。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f3/341002/99ca5a4063c7/nar00296-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f3/341002/99ca5a4063c7/nar00296-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f3/341002/99ca5a4063c7/nar00296-0074-a.jpg

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