Wang Jia, Sun Tong, Yang Ming, Lin Dong-Xin, Tan Wen, Li Ke-Ji, Xiao Ying
Department of Nutrition and Food Hygiene, Peking University Health Science Center, Beijing 100083, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2008 Jul;42(7):511-4.
This study examined whether the two polymorphisms of GPX1 (198Pro--> Leu) and TXNRD2 (370Lys-->Arg) contributed alone or in combination, to the risk of gastric cancer development.
A total of 361 patients with gastric cancer and 363 cancer-free controls were recruited and their genotypes of the two polymorphisms were determined by polymerase chain reaction-based restrictive fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) and 95% confidence interval (CI) were computed using unconditional logistic regression model.
GPX1 and TXNRD2 polymorphisms individually were not associated with the risk of gastric cancer. Gene-gene interaction of GPX1 and TXNRD2 polymorphisms decreased the risk of gastric cancer. Carrying the protective genotype might decrease the risk at 62% (OR = 0.38, 95% CI = 0.26-0.55, P < 0.001) as compared with the risk genotype.
The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer.
本研究旨在探讨谷胱甘肽过氧化物酶1（GPX1，198Pro→Leu）和硫氧还蛋白还原酶2（TXNRD2，370Lys→Arg）的两种多态性单独或联合作用是否会增加胃癌发生风险。
共招募361例胃癌患者和363例无癌对照者，采用基于聚合酶链反应的限制性片段长度多态性（PCR-RFLP）方法检测两种多态性的基因型。使用非条件逻辑回归模型计算比值比（OR）和95%置信区间（CI）。
GPX1和TXNRD2多态性单独与胃癌风险无关。GPX1和TXNRD2多态性的基因-基因相互作用降低了胃癌风险。与风险基因型相比，携带保护性基因型可使风险降低62%（OR = 0.38，95%CI = 0.26 - 0.55，P < 0.001）。
GPX1 198 Pro/Pro和TXNRD2 370Arg/Arg基因型可能与胃癌的遗传易感性有关。
