Heiman Gary A, King Robert A, Tischfield Jay A
Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA.
BMC Med Genomics. 2008 Nov 26;1:58. doi: 10.1186/1755-8794-1-58.
Tourette Syndrome is a neuropsychiatric disorder characterized by chronic motor and phonic tics. Affected individuals and their family members are at an increased risk for other neuropsychiatric conditions including obsessive-compulsive disorder and attention deficit hyperactivity disorder. While there is consistent evidence that genetic factors play a significant etiologic role, no replicable susceptibility alleles have thus far been identified.
Here we discuss a sharing resource of clinical and genetic data, the New Jersey Center for Tourette Syndrome Sharing Repository, whose goal is to provide clinical data, DNA, and lymphoblastoid cell lines to qualified researchers.
Opening access to the data and patient material to the widest possible research community will hasten the identification of causal genetic factors and facilitate better understanding and treatment of this often impairing disorder.
抽动秽语综合征是一种神经精神障碍，其特征为慢性运动性和发声性抽动。受影响的个体及其家庭成员患其他神经精神疾病的风险增加，包括强迫症和注意力缺陷多动障碍。虽然有一致的证据表明遗传因素在病因学中起重要作用，但迄今为止尚未鉴定出可重复的易感等位基因。
在此，我们讨论一个临床和遗传数据共享资源，即新泽西抽动秽语综合征共享库，其目标是向合格的研究人员提供临床数据、DNA和淋巴母细胞系。
向尽可能广泛的研究群体开放数据和患者材料的获取将加速因果遗传因素的鉴定，并有助于更好地理解和治疗这种常常造成损害的疾病。
