不可切除肺癌患者血清中可溶性白细胞介素-2受体和可溶性CD8抗原水平
Soluble interleukin-2 receptor and soluble CD8 antigen levels in serum from patients with non-resectable lung cancer.
作者信息
Vibe-Petersen J, Tvede N, Diamant M, Kjerulff A A, Sørensen H R, Andersen V
机构信息
Department of Medicine TTA, Rigshospitalet, University of Copenhagen, Denmark.
出版信息
Cancer Immunol Immunother. 1991;33(2):121-7. doi: 10.1007/BF01742540.
In a preliminary longitudinal study two women with histologically verified adenocarcinoma of the lung, without simultaneous infectious or inflammatory conditions, were seen every 2 weeks until death. In one of the patients serum soluble interleukin-2 receptor (sIL-2R) levels rose progressively while the levels for the other patient increased during the second half of the observation period. Serum soluble CD8 antigen (sCD8 Ag) showed a pattern dissimilar to the one for sIL-2R. In a retrospective cross-sectional study circulating levels of sIL-2R and sCD8 Ag were measured before explorative thoracotomy in a total of 65 patients with histologically proven non-resectable carcinoma of the lung. The sIL-2R levels were significantly increased independently of histological subclassification while sCD8 Ag was increased only in patients with small-cell lung cancer. There was no correlation between pre-operative values and length of survival.
在一项初步的纵向研究中，对两名经组织学证实为肺癌腺癌且无同时存在感染或炎症情况的女性患者，每两周观察一次直至死亡。其中一名患者的血清可溶性白细胞介素-2受体（sIL-2R）水平逐渐升高，而另一名患者的该水平在观察期后半段升高。血清可溶性CD8抗原（sCD8 Ag）呈现出与sIL-2R不同的模式。在一项回顾性横断面研究中，对总共65例经组织学证实为不可切除肺癌的患者在开胸探查术前测量了sIL-2R和sCD8 Ag的循环水平。sIL-2R水平显著升高，与组织学亚分类无关，而sCD8 Ag仅在小细胞肺癌患者中升高。术前值与生存期之间无相关性。
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