系统性红斑狼疮中的可溶性白细胞介素-2受体

Soluble interleukin-2 receptors in systemic lupus erythematosus.

作者信息

Wolf R E, Brelsford W G

机构信息

Department of Medicine, LSU Medical Center, Shreveport 71130.

出版信息

Arthritis Rheum. 1988 Jun;31(6):729-35. doi: 10.1002/art.1780310605.

DOI:10.1002/art.1780310605

PMID:3132927

Abstract

We studied levels of soluble interleukin-2 receptors (IL-2R), which are released by activated lymphocytes, in 139 serum samples from 12 patients with systemic lupus erythematosus (SLE). Concentrations of soluble IL-2R were significantly increased in SLE patients compared with controls (P less than 0.001), and they were significantly higher in patients during active SLE defined by low C3 levels (P less than 0.001), low C4 levels (P less than 0.001), or proteinuria (P less than 0.05) than during inactive SLE. Elevated levels of soluble IL-2R correlated with hypocomplementemia in longitudinal studies (P less than 0.001). Measurement of serum concentrations of soluble IL-2R may provide a sensitive and specific method for monitoring disease activity and immune activation in patients with SLE.

摘要

我们研究了12例系统性红斑狼疮（SLE）患者的139份血清样本中可溶性白细胞介素-2受体（IL-2R）的水平，该受体由活化淋巴细胞释放。与对照组相比，SLE患者可溶性IL-2R的浓度显著升高（P<0.001），且在以低C3水平（P<0.001）、低C4水平（P<0.001）或蛋白尿（P<0.05）定义的SLE活动期患者中，其水平显著高于非活动期患者。在纵向研究中，可溶性IL-2R水平升高与补体低下相关（P<0.001）。检测血清可溶性IL-2R浓度可能为监测SLE患者的疾病活动和免疫激活提供一种敏感且特异的方法。