Semenzato G, Cipriani A, Trentin L, Zambello R, Masciarelli M, Vinante F, Chilosi M, Pizzolo G
Sarcoidosis. 1987 Mar;4(1):25-7.
We provide evidence that high levels of soluble interleukin-2 receptor (sIL-2R) are present in the serum of patients with sarcoidosis. Because sIL-2R is capable of binding to its ligand (IL-2), the increased serum levels of this molecule could induce a starvation of IL-2. This mechanism could help to explain a number of immunological abnormalities extensively reported in these patients and generally attributed to not yet identified serum inhibitory factors.
我们提供的证据表明，结节病患者血清中存在高水平的可溶性白细胞介素-2受体（sIL-2R）。由于sIL-2R能够与其配体（IL-2）结合，该分子血清水平的升高可能导致IL-2耗竭。这一机制有助于解释这些患者中广泛报道的一些免疫异常现象，这些异常现象通常归因于尚未确定的血清抑制因子。
