从番荔枝科植物阔叶番荔枝种子中分离出的两种新的相邻双四氢呋喃类番荔枝内酯。

Two new adjacent bis-tetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia.

作者信息

Rodrigues dos Santos Lima Luciana Alves, Santos Pimenta Lúcia Pinheiro, Diamantino Boaventura Maria Amélia

机构信息

Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

出版信息

Planta Med. 2009 Jan;75(1):80-3. doi: 10.1055/s-0028-1088359. Epub 2008 Nov 27.

DOI:10.1055/s-0028-1088359

PMID:19039734

Abstract

Two new adjacent bis-THF annonaceous acetogenins, 9-hydroxyfolianin (1) and folianin B (2), together with two known acetogenins, asimicin (3) and bullatacin (4), significantly bioactives in brine shrimp lethality test, were isolated from seeds of Annona cornifolia A. St. Hil (Annonaceae). Their structures were elucidated by NMR and ESI-MS analysis, and relative configurations were established. The absolute configuration around the THF rings of 1 was defined by Mosher esters methodology and circular dichroism.

摘要

从番荔枝科植物多叶番荔枝（Annona cornifolia A. St. Hil）的种子中分离出两种新的相邻双四氢呋喃类番荔枝内酯，9-羟基番荔枝宁（1）和番荔枝宁B（2），以及两种已知的番荔枝内酯，阿西米辛（3）和布拉他辛（4），它们在卤虫致死试验中具有显著生物活性。通过核磁共振（NMR）和电喷雾电离质谱（ESI-MS）分析阐明了它们的结构，并确定了相对构型。1的四氢呋喃环周围的绝对构型通过莫舍尔酯法和圆二色性确定。