Elder M G, Lawson J P, Elstein M, Nuttall I D
Institute of Obstetrics and Gynaecology, University of London, Hammersmith Hospital.
Contraception. 1991 Feb;43(2):129-37. doi: 10.1016/0010-7824(91)90040-m.
The efficacy and acceptability of a levonorgestrel-releasing intravaginal ring (IVR) for contraception was assessed in a British cohort studied as part of a multicentre, multinational clinical trial performed under the auspices of the World Health Organisation. One-hundred-and-fifty women took part in the study in two UK centres and completed 1417.5 months of method use. Fifty-nine women discontinued use of the IVR before the end of one year giving an overall discontinuation rate of 39.9 per 100 woman-years. The discontinuation for pregnancy with the ring in situ, was 3.0 per 100 woman-years (life table analysis). Menstrual disturbance, vaginal problems and involuntary expulsion resulted in discontinuation rates of 8.9, 8.4 and 1.6 per 100 woman-years, respectively. This method is an acceptable and effective method of contraception for women.
作为由世界卫生组织主持开展的一项多中心、跨国临床试验的一部分，在一个英国队列中评估了左炔诺孕酮阴道环（IVR）用于避孕的有效性和可接受性。150名女性在英国的两个中心参与了该研究，共完成了1417.5个月的方法使用。59名女性在一年结束前停止使用IVR，总体停药率为每100妇女年39.9例。在位使用阴道环期间因妊娠导致的停药率为每100妇女年3.0例（生命表分析）。月经紊乱、阴道问题和意外排出导致的停药率分别为每100妇女年8.9例、8.4例和1.6例。这种方法对女性来说是一种可接受且有效的避孕方法。
