den Hartog Laurens, Slater James J R Huddleston, Vissink Arjan, Meijer Henny J A, Raghoebar Gerry M
Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
J Clin Periodontol. 2008 Dec;35(12):1073-86. doi: 10.1111/j.1600-051X.2008.01330.x.
This study evaluated, through a systematic review of the literature, the outcome of single-implant restorations in the aesthetic zone with natural adjacent teeth, thereby addressing immediate, early and conventional implant approaches.
MEDLINE (1950-2008), EMBASE (1966-2008), and CENTRAL (1800-2008) were searched to identify eligible studies. Two reviewers independently assessed the methodological quality using specific study-design-related assessment forms.
Out of 86 primarily selected articles, 19 studies fulfilled the inclusion criteria. A meta-analysis showed an overall survival rate of 95.5% [95% confidence interval: (93.0-97.1)] after 1 year. A stratified meta-analysis revealed no differences in survival between immediate, early and conventional implant strategies. Little marginal peri-implant bone resorption was found together with low incidence of biological and technical complications. No significant differences in outcome measures were reported in clinical trials comparing immediate, early or conventional implant strategies.
The included literature suggested that promising short-term results could be achieved for immediate, early and conventional single-implants in the aesthetic zone. However, important parameters as aesthetic outcome, soft-tissue aspects, and patient satisfaction were clearly underexposed. The question whether immediate and early single-implant therapies would result in better treatment outcomes remained inconclusive due to lack of well-designed controlled clinical studies.
本研究通过对文献的系统回顾，评估美学区域内单颗种植修复体与天然邻牙的修复效果，从而探讨即刻种植、早期种植和传统种植方法。
检索MEDLINE（1950 - 2008年）、EMBASE（1966 - 2008年）和CENTRAL（1800 - 2008年）以确定符合条件的研究。两名评价者使用与特定研究设计相关的评价表独立评估方法学质量。
在初步筛选出的86篇文章中，19项研究符合纳入标准。一项荟萃分析显示，1年后总体生存率为95.5%[95%置信区间：（93.0 - 97.1）]。分层荟萃分析显示，即刻种植、早期种植和传统种植策略在生存率方面无差异。种植体周围边缘骨吸收很少，生物学和技术并发症发生率较低。在比较即刻种植、早期种植或传统种植策略的临床试验中，未报告结局指标有显著差异。
纳入的文献表明，美学区域内即刻种植、早期种植和传统单颗种植体可取得较好的短期效果。然而，美学效果、软组织方面和患者满意度等重要参数明显未得到充分探讨。由于缺乏设计良好的对照临床研究，即刻种植和早期单颗种植治疗是否会带来更好的治疗效果这一问题仍无定论。
