Murphy James J, Tawfeeq Mansour, Chang Brett, Nadel Helen
Department of Pediatric Surgery, British Columbia Children's Hospital, Vancouver, British Columbia, Canada V6H 3V4.
J Pediatr Surg. 2008 Dec;43(12):2186-92. doi: 10.1016/j.jpedsurg.2008.08.064.
Positron emission tomography/computerized tomography (PET/CT) scan provides both functional and anatomical information in a single diagnostic test. It has the potential to be a valuable tool in the evaluation of pediatric abdominal tumors. The goal of this study is to report our early experience with this technology.
Children who underwent PET/CT scan in the workup for abdominal neoplasms between July 2005 and January 2008 were identified. Retrospective review of all radiologic studies, operative notes, and pathologic reports was undertaken.
A total of 36 patients were collected. These included Burkitt's lymphoma (8), neuroblastoma (7), rhabdomyosarcoma (6), ovarian tumor (3), Wilms' tumor (2), hepatocellular carcinoma (2), paraganglioma (1), germ cell tumor (1), undifferentiated sarcoma (1), renal primitive neuroectodermal tumor (1), gastrointestinal stromal tumor (1), adrenocortical carcinoma (1), inflammatory pseudotumor (1), and adrenal adenoma (1). All neoplasms were fluorodeoxyglucose (FDG) were avid. Our experience identified several potential uses for PET/CT scan in this group of patients. These include (1) preoperative staging, (2) selection of appropriate site for biopsy, (3) identification of occult metastatic disease, (4) follow-up for residual or recurrent disease, and (5) assessment of response to chemotherapy. It can also be valuable when the standard diagnostic studies are equivocal or conflicting.
Preliminary data indicate that PET/CT is a promising tool in the evaluation of pediatric abdominal malignancies. The delineation of the exact role of this diagnostic modality will require additional experience.
正电子发射断层扫描/计算机断层扫描（PET/CT）在一次诊断检查中可同时提供功能和解剖信息。它有可能成为评估小儿腹部肿瘤的一项有价值的工具。本研究的目的是报告我们使用该技术的早期经验。
确定2005年7月至2008年1月期间因腹部肿瘤检查而接受PET/CT扫描的儿童。对所有放射学研究、手术记录和病理报告进行回顾性分析。
共收集36例患者。其中包括伯基特淋巴瘤（8例）、神经母细胞瘤（7例）、横纹肌肉瘤（6例）、卵巢肿瘤（3例）、肾母细胞瘤（2例）、肝细胞癌（2例）、副神经节瘤（1例）、生殖细胞瘤（1例）、未分化肉瘤（1例）、肾原始神经外胚层肿瘤（1例）、胃肠道间质瘤（1例）、肾上腺皮质癌（1例）、炎性假瘤（1例）和肾上腺腺瘤（1例）。所有肿瘤对氟脱氧葡萄糖（FDG）摄取均增加。我们的经验确定了PET/CT扫描在这组患者中的几种潜在用途。这些用途包括：（1）术前分期；（2）选择合适的活检部位；（3）识别隐匿性转移疾病；（4）对残留或复发性疾病进行随访；（5）评估化疗反应。当标准诊断研究结果不明确或相互矛盾时，它也很有价值。
初步数据表明，PET/CT是评估小儿腹部恶性肿瘤的一种有前景的工具。确定这种诊断方式的确切作用还需要更多经验。
