Todd William U, Wenig Bruce M
Department of Pathology and Laboratory Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Otolaryngol Clin North Am. 2008 Dec;41(6):1079-94, vii-viii. doi: 10.1016/j.otc.2008.08.001.
The majority of recurrent thyroid carcinomas are histologically differentiated and readily diagnosed by light microscopy or immunohistochemical staining. Infrequently, recurrent carcinoma may be less differentiated than the index lesion, creating diagnostic challenges. Complicating issues include thyroid carcinomas that recur years after initial diagnosis or without clinical elevation of serum thyroglobulin. With a favorable outcome and lengthy survival rates after initial diagnosis of differentiated thyroid carcinoma, there is a greater chance for these carcinomas to recur and as less differentiated carcinoma. As more advanced treatment techniques enter daily practice, the pathology of recurrent thyroid carcinomas will be better defined and more readily diagnosed.
大多数复发性甲状腺癌在组织学上是分化良好的，通过光学显微镜或免疫组化染色很容易诊断。复发性癌偶尔可能比分发灶分化程度低，这给诊断带来了挑战。复杂的问题包括在初次诊断数年之后复发的甲状腺癌，或者血清甲状腺球蛋白没有临床升高的情况。由于分化型甲状腺癌初次诊断后预后良好且生存率长，这些癌复发并成为低分化癌的可能性更大。随着更先进的治疗技术应用于日常实践，复发性甲状腺癌的病理学将得到更好的界定，更容易诊断。
