Hellyer P W, Freeman L C, Hubbell J A
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus.
Vet Surg. 1991 Mar-Apr;20(2):143-7. doi: 10.1111/j.1532-950x.1991.tb00324.x.
Anesthesia was induced in 14 greyhounds with a mixture of diazepam or midazolam (0.28 mg/kg) and ketamine (5.5 mg/kg), and maintained with halothane. There were no significant differences in weight, age, or duration of anesthesia between the treatment groups. Time to intubation with diazepam-ketamine (4.07 +/- 1.43 min) was significantly longer than with midazolam-ketamine (2.73 +/- 0.84 min). Heart rate, respiratory rate, PaCO2, and arterial pH did not vary significantly during anesthesia in either treatment group. Arterial blood pressures, PaO2, halothane vaporizer setting, and body temperature changed significantly from baseline values in both treatment groups during anesthesia. Times to sternal recumbency and times to standing were not significantly different. These data suggest that both diazepam-ketamine and midazolam-ketamine are useful anesthetic combinations in greyhounds. In combination with ketamine, midazolam offers little advantage over diazepam.
对14只灵缇犬使用地西泮或咪达唑仑（0.28毫克/千克）与氯胺酮（5.5毫克/千克）的混合物诱导麻醉，并使用氟烷维持麻醉。各治疗组之间在体重、年龄或麻醉持续时间上无显著差异。使用地西泮 - 氯胺酮插管时间（4.07±1.43分钟）显著长于使用咪达唑仑 - 氯胺酮（2.73±0.84分钟）。在任一治疗组中，麻醉期间心率、呼吸频率、动脉血二氧化碳分压和动脉pH值均无显著变化。在麻醉期间，两个治疗组的动脉血压、动脉血氧分压、氟烷蒸发器设置和体温与基线值相比均有显著变化。侧卧时间和站立时间无显著差异。这些数据表明，地西泮 - 氯胺酮和咪达唑仑 - 氯胺酮都是灵缇犬有用的麻醉组合。与氯胺酮联合使用时，咪达唑仑相对于地西泮几乎没有优势。
