Department of Internal Medicine, Division of Immunotherapy and Gene Therapy, José Carreras Center for Immunotherapy and Gene Therapy, Saarland University Medical Center, 66421 Homburg, Saarland Germany.
Clin Epigenetics. 2010 Dec;1(3-4):71-83. doi: 10.1007/s13148-010-0008-0. Epub 2010 Aug 20.
Aging is the natural trace that time leaves behind on life during blossom and maturation, culminating in senescence and death. This process is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as diabetes, cancer, cardiovascular disease, and neurodegeneration. Based on the fact that both sirtuin expression and activity appear to be upregulated in some types of cancer while they are being downregulated in others, there is quite some controversy stirring up as to the role of sirtuins, acting as cancer suppressors in some cases while under other circumstances they may promote cellular malignancy. It is therefore currently quite unclear as to what extent and under which particular circumstances sirtuin activators and/or inhibitors will find their place in the treatment of age-related disease and cancer. In this review, we take an effort to bring together the highlights of sirtuin research in order to shed some light on the mechanistic impact that sirtuins have on the pathogenesis of cellular malignancy.
衰老是生命在开花和成熟过程中时间留下的自然痕迹，最终导致衰老和死亡。这个过程伴随着多个器官系统健康功能的下降，导致糖尿病、癌症、心血管疾病和神经退行性疾病等疾病的发病率和死亡率增加。鉴于在某些类型的癌症中，sirtuin 的表达和活性似乎上调，而在其他类型的癌症中下调，因此关于 sirtuin 的作用存在相当大的争议，在某些情况下，sirtuin 作为癌症抑制剂，而在其他情况下，它们可能促进细胞恶性。因此，目前尚不清楚在何种程度上以及在何种特定情况下，sirtuin 激活剂和/或抑制剂将在治疗与年龄相关的疾病和癌症方面发挥作用。在这篇综述中，我们努力汇集了 sirtuin 研究的重点，以期阐明 sirtuin 对细胞恶性发生的机制影响。
