Le Mouel S, Gaston A, Paule B
Service d'orthopédie, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France.
Prog Urol. 2008 Dec;18(13):1045-9. doi: 10.1016/j.purol.2008.08.004. Epub 2008 Sep 24.
Surgery for osseous metastases seems to improve the patients with renal cell carcinoma. The goal of this study is to evaluate the efficacy and safety of surgery for osseous metastases from renal cell carcinoma.
We performed 21 surgery for osseous metastases in 13 patients who have been treated for metastatic renal cell carcinoma at one institution between 2001 and 2007. The surgical procedure included curetage with cementing and or internal fixation, in bloc resection or surgical decompressive procedure. Disease-free and overall survival was calculated using Kaplan-Meïer analysis.
The overall patient survival rate at one year was 84%. The overall median survival time was 23months (IC95%; 16,9-78,1%). The disease-free survival was 19 months (IC95%: 26,7%-80,9%) after surgery. Positive margins were observed in 9 patients (R2) and negative margins in 8 patients (R0). R0 and R2 resections have no impact on local relapse. Minor complications occurred in two patients. There was no intra- or postoperative hemorrhage.
Surgery of osseous metastases is safe and effective and seems to improve outcomes of metastatic renal cell carcinoma.
