Hafez M, Aboul Hassan S, el-Tahan H, el-Shennawy F, Khashaba M, al-Tonbary Y, el-Morsi Z, el-Sallab S, el-Desoky I, el-Shazly A
Pediatric Department, Faculty of Medicine, Mansoura University, Egypt.
Am J Trop Med Hyg. 1991 Apr;44(4):424-33. doi: 10.4269/ajtmh.1991.44.424.
In 19 children with hepatic fibrosis as the result of continued schistosomiasis mansoni and 20 children without hepatic fibrosis, the following studies were carried out: HLA antigen typing for 30 antigens, immune response of T lymphocytes to schistosome antigen by measuring DNA synthesis evidenced by 3H-thymidine uptake, and measurement of total OKT3+, OKT4+, and OKT8+ cells using monoclonal antibodies. Patients with hepatic fibrosis were mostly high responders in contrast with those without fibrosis. High immune response and susceptibility to post-schistosomal hepatic fibrosis were associated with a high frequency of A2 and B12 antigens and a lack of DR2 antigens, while low response was associated with the presence of the DR2 antigen. The T4+:T8+ ratio showed increased suppressor proportions in patients with low immune response and/or with no hepatic fibrosis. We suggest an immunogenetic susceptibility for post-schistosomal hepatic fibrosis, probably controlled by HLA-linked genes via the suppressor T cells.
对19名因曼氏血吸虫病持续感染导致肝纤维化的儿童和20名无肝纤维化的儿童进行了以下研究：对30种抗原进行HLA抗原分型，通过测量³H-胸腺嘧啶核苷摄取所证明的DNA合成来检测T淋巴细胞对血吸虫抗原的免疫反应，以及使用单克隆抗体测量OKT3⁺、OKT4⁺和OKT8⁺细胞的总数。与无纤维化的患者相比，肝纤维化患者大多为高反应者。高免疫反应和对血吸虫后肝纤维化的易感性与A2和B12抗原的高频率以及DR2抗原的缺乏有关，而低反应与DR2抗原的存在有关。T4⁺:T8⁺比值显示，免疫反应低和/或无肝纤维化的患者中抑制细胞比例增加。我们认为血吸虫后肝纤维化存在免疫遗传易感性，可能由HLA连锁基因通过抑制性T细胞控制。
