人类血吸虫病后肝硬化患者的免疫遗传学分析。
Immunogenetic analysis of patients with post-schistosomal liver cirrhosis in man.
作者信息
Ohta N, Nishimura Y K, Iuchi M, Sasazuki T
出版信息
Clin Exp Immunol. 1982 Sep;49(3):493-9.
Immune responsiveness of 121 patients with post-schistosomal liver cirrhosis to schistosomal antigens was investigated. Out of 78 patients, only five (6.4%) showed low responsiveness to schistosomal adult worm antigen whereas 73 (93.6%) were high responders. Out of 57 healthy individuals with previous schistosomal infection, low responders were found in 17.5%. The frequency of low responders to schistosomal adult worm antigen was significantly decreased in the patients with post-schistosomal liver cirrhosis (P less than 0.05). Out of 121 patients, a significant increase in frequency of HLA-Bw44-DEn haplotype was observed (corrected P less than 0.02). On the other hand, HLA-Bw52-Dw12 haplotype which was reported to be in strong linkage disequilibrium with an immune suppression gene for schistosomal adult worm antigen was significantly decreased (corrected P less than 0.005). These observations suggested that an HLA-linked immune suppression gene controlled susceptibility or resistance to post-schistosomal liver cirrhosis through regulation of immune responsiveness of the hosts to schistosomal antigen in man.
对121例血吸虫性肝硬变患者针对血吸虫抗原的免疫反应性进行了研究。在78例患者中，只有5例（6.4%）对血吸虫成虫抗原表现出低反应性，而73例（93.6%）为高反应者。在57例既往有血吸虫感染的健康个体中，发现低反应者占17.5%。血吸虫性肝硬变患者中对血吸虫成虫抗原低反应者的频率显著降低（P<0.05）。在121例患者中，观察到HLA - Bw44 - DEn单倍型频率显著增加（校正P<0.02）。另一方面，据报道与针对血吸虫成虫抗原的免疫抑制基因存在强连锁不平衡的HLA - Bw52 - Dw12单倍型显著减少（校正P<0.005）。这些观察结果提示，一个与HLA相关的免疫抑制基因通过调节人体宿主对血吸虫抗原的免疫反应性来控制对血吸虫性肝硬变的易感性或抵抗力。
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