Nakamura Seikou, Okazaki Yoshie, Ninomiya Kiyofumi, Morikawa Toshio, Matsuda Hisashi, Yoshikawa Masayuki
Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan.
Chem Pharm Bull (Tokyo). 2008 Dec;56(12):1704-9. doi: 10.1248/cpb.56.1704.
The 80% aqueous acetone extract from the flowers of Hedychium coronarium was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. On the other hand, two new labdane-type diterpene glycosides, coronalactosides I (1) and II (2), and a new labdane-type trinorditerpene, coronadiene (3), were isolated together with 8 known compounds from the extracts, which were obtained with chloroform and 80% aqueous acetone from the flowers of H. coronarium. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, coronaririn C and 15-hydroxylabda-8(17),11,13-trien-16,15-olide, displayed hepatoprotective effects, which were stronger than that of the hepatoprotective agent, silybin.
研究发现，白姜花花朵的80%丙酮水溶液提取物对原代培养的小鼠肝细胞中D - 半乳糖胺诱导的细胞毒性具有保护作用。另一方面，从白姜花花朵的氯仿提取物和80%丙酮水溶液提取物中分离出两种新的半日花烷型二萜糖苷，冠状乳糖苷I（1）和II（2），以及一种新的半日花烷型三降二萜，冠状二烯（3），同时还分离出8种已知化合物。根据化学和物理化学证据阐明了新成分的结构。此外，主要成分冠状瑞香素C和15 - 羟基半日花 - 8(17),11,13 - 三烯 - 16,15 - 内酯表现出比保肝剂水飞蓟宾更强的保肝作用。
