药用花卉。二十四。白姜花花朵成分的化学结构及保肝作用。

Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium.

作者信息

Nakamura Seikou, Okazaki Yoshie, Ninomiya Kiyofumi, Morikawa Toshio, Matsuda Hisashi, Yoshikawa Masayuki

机构信息

Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2008 Dec;56(12):1704-9. doi: 10.1248/cpb.56.1704.

DOI:10.1248/cpb.56.1704

PMID:19043243

Abstract

The 80% aqueous acetone extract from the flowers of Hedychium coronarium was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. On the other hand, two new labdane-type diterpene glycosides, coronalactosides I (1) and II (2), and a new labdane-type trinorditerpene, coronadiene (3), were isolated together with 8 known compounds from the extracts, which were obtained with chloroform and 80% aqueous acetone from the flowers of H. coronarium. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, coronaririn C and 15-hydroxylabda-8(17),11,13-trien-16,15-olide, displayed hepatoprotective effects, which were stronger than that of the hepatoprotective agent, silybin.

摘要

研究发现，白姜花花朵的80%丙酮水溶液提取物对原代培养的小鼠肝细胞中D - 半乳糖胺诱导的细胞毒性具有保护作用。另一方面，从白姜花花朵的氯仿提取物和80%丙酮水溶液提取物中分离出两种新的半日花烷型二萜糖苷，冠状乳糖苷I（1）和II（2），以及一种新的半日花烷型三降二萜，冠状二烯（3），同时还分离出8种已知化合物。根据化学和物理化学证据阐明了新成分的结构。此外，主要成分冠状瑞香素C和15 - 羟基半日花 - 8(17),11,13 - 三烯 - 16,15 - 内酯表现出比保肝剂水飞蓟宾更强的保肝作用。