来自传统藏药鹅绒委陵菜的具有保肝活性的鞣花酸糖苷。
Ellagic acid glycosides with hepatoprotective activity from traditional Tibetan medicine Potentilla anserina.
作者信息
Morikawa Toshio, Imura Katsuya, Akagi Yoshinori, Muraoka Osamu, Ninomiya Kiyofumi
机构信息
Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
Antiaging Center, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
出版信息
J Nat Med. 2018 Jan;72(1):317-325. doi: 10.1007/s11418-017-1137-y. Epub 2017 Oct 10.
Two new gallic acid glycosides, potentillanosides G (1) and H (2), were newly isolated from the methanol extract of the tuberous roots of Potentilla anserina (Rosaceae), together with a known compound, ellagic acid 3-O-α-L-rhamnopyranoside (3). Their structures were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, potentillanoside H (2, IC = 99.5 μM) was found to show hepatoprotective activity.
从鹅绒委陵菜（蔷薇科）块根的甲醇提取物中，新分离出两种新的没食子酸糖苷，委陵菜苷G（1）和H（2），以及一种已知化合物，鞣花酸3-O-α-L-鼠李糖苷（3）。基于化学和物理化学证据阐明了它们的结构。在这些成分中，发现委陵菜苷H（2，IC = 99.5 μM）具有保肝活性。
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