两种新的酚苷——山柰苷A和B以及小花山柰根茎中的保肝成分的结构
Structures of two new phenolic glycosides, kaempferiaosides A and B, and hepatoprotective constituents from the rhizomes of Kaempferia parviflora.
作者信息
Chaipech Saowanee, Morikawa Toshio, Ninomiya Kiyofumi, Yoshikawa Masayuki, Pongpiriyadacha Yutana, Hayakawa Takao, Muraoka Osamu
机构信息
Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577- 8502, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2012;60(1):62-9. doi: 10.1248/cpb.60.62.
Two new phenolic glycosides, kaempferiaosides A and B were isolated from the rhizomes of Kaempferia parviflora (Zingiberaceae) together with 24 known compounds. Their structures including absolute stereochemistry were elucidated on the basis of chemical and spectroscopic evidence. Among the isolates, 5,3'-dihydroxy-3,7,4'-trimethoxyflavone showed higher activity than silybin, a commercial hepatoprotective agent.
从小花山柰（姜科）的根茎中分离出两种新的酚苷，山柰苷A和B，以及24种已知化合物。基于化学和光谱证据阐明了它们的结构，包括绝对立体化学。在分离出的化合物中，5,3'-二羟基-3,7,4'-三甲氧基黄酮显示出比水飞蓟宾（一种商业保肝剂）更高的活性。
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