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来自姜花的新型半日花烷型二萜类化合物及抗炎成分。

New Labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium.

作者信息

Chen Jih-Jung, Ting Chia-Wei, Wu Yi-Chin, Hwang Tsong-Long, Cheng Ming-Jen, Sung Ping-Jyun, Wang Tai-Chi, Chen Jinn-Fen

机构信息

Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan.

出版信息

Int J Mol Sci. 2013 Jun 25;14(7):13063-77. doi: 10.3390/ijms140713063.

DOI:10.3390/ijms140713063
PMID:23799360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3742174/
Abstract

Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3-6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.

摘要

从姜花的根茎中分离出了四种新的半日花烷型二萜类化合物

姜花冠冕素（1）、过氧冠冕素D（2）、7β-羟基卡卡拉他林A（3）和（E）-7β-羟基-6-氧代-赖百当-8（17），12-二烯-15，16-二醛（4），以及13种已知化合物（5-17）。通过光谱和质谱分析确定了这些新化合物的结构。化合物3、5、6和10对人中性粒细胞在响应甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸/细胞松弛素B（fMLP/CB）时产生超氧阴离子具有抑制作用（IC50值≤4.52μg/mL）。化合物3-6、10和11以IC50值≤6.17μg/mL抑制fMLP/CB诱导的弹性蛋白酶释放。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/3bd0229d5bb3/ijms-14-13063f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/2add32deb50f/ijms-14-13063f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/d79ab28ab199/ijms-14-13063f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/aaaef6f8977b/ijms-14-13063f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/a8ded59abee6/ijms-14-13063f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/3bd0229d5bb3/ijms-14-13063f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/2add32deb50f/ijms-14-13063f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/20e3d5636110/ijms-14-13063f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/d79ab28ab199/ijms-14-13063f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/aaaef6f8977b/ijms-14-13063f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/a8ded59abee6/ijms-14-13063f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5240/3742174/3bd0229d5bb3/ijms-14-13063f6.jpg

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