水翁花芽中的抗氧化黄酮类化合物。

Antioxidative flavonoids from Cleistocalyx operculatus buds.

作者信息

Min Byung-Sun, Thu Cao Van, Dat Nguyen Tien, Dang Nguyen Hai, Jang Han-Su, Hung Tran Manh

机构信息

College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea.

出版信息

Chem Pharm Bull (Tokyo). 2008 Dec;56(12):1725-8. doi: 10.1248/cpb.56.1725.

DOI:10.1248/cpb.56.1725

PMID:19043247

Abstract

Four new flavonoids, 3'-formyl-4',6',4-trihydroxy-2'-methoxy-5'-methylchalcone (1), 3'-formyl-6',4-dihydroxy-2'-methoxy-5'-methylchalcone 4'-O-beta-D-glucopyranoside (2), (2S)-8-formyl-6-methylnaringenin (3), and (2S)-8-formyl-6-methylnaringenin 7-O-beta-D-glucopyranoside (4) were isolated from the buds of Cleistocalyx operculatus (Myrtaceae). The structures of the new metabolites (1-4) were determined on the basic of spectroscopic analyses including 2 dimensional NMR. Compounds 1 and 3 exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity with IC(50) values of 22.8 and 27.1 microM, respectively.

摘要

从水翁（桃金娘科）的芽中分离出四种新黄酮类化合物，分别为3'-甲酰基-4',6',4-三羟基-2'-甲氧基-5'-甲基查尔酮（1）、3'-甲酰基-6',4-二羟基-2'-甲氧基-5'-甲基查尔酮4'-O-β-D-吡喃葡萄糖苷（2）、(2S)-8-甲酰基-6-甲基柚皮素（3）和(2S)-8-甲酰基-6-甲基柚皮素7-O-β-D-吡喃葡萄糖苷（4）。通过包括二维核磁共振在内的光谱分析确定了新代谢产物（1-4）的结构。化合物1和3表现出1,1-二苯基-2-苦基肼自由基清除活性，IC(50)值分别为22.8和27.1 microM。