从突尼斯盐角草中提取的新抗氧化二苄基衍生物和异黄酮
New antioxidant bibenzyl derivative and isoflavonoid from the Tunisian Salsola tetrandra Folsk.
机构信息
Department of Chemistry, Laboratory of Natural Products, Faculty of Sciences, University of Monastir, Monastir 5000, Tunisia.
出版信息
Nat Prod Res. 2012;26(3):235-42. doi: 10.1080/14786419.2010.536950. Epub 2011 Aug 11.
Two new phytochemical compounds, Tetranins A and B, 1-(3,5'-dihydroxy-4'-méthoxyphenyl)-2-phenylethanol 1 and 5,2'-dihydroxy-5'-methoxy-6,7-methylenedioxy-isoflavone 2, were isolated from the EtOAc extract of Salsola tetrandra roots. They exhibited a significant antioxidant effect in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and 2,2'-azinobis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assays. Their structures were elucidated by extensive spectroscopic methods including 1-D-((1)H and (13)C) and 2-D-NMR experiments (CHcorr, HMBC, (1)H-(1)H COSY and NOESY) as well as high-resolution ES-MS and they were found to be quite active as antioxidants in the DPPH and ABTS assays.
从四翅滨藜根的 EtOAc 提取物中分离得到了两种新的植物化学化合物，即 Tetranins A 和 B，1-(3,5'-二羟基-4'-甲氧基苯基)-2-苯乙醇 1 和 5,2'-二羟基-5'-甲氧基-6,7-亚甲基二氧基异黄酮 2。它们在 1,1-二苯基-2-苦基肼（DPPH）自由基和 2,2'-联氮双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）测定中表现出显著的抗氧化作用。通过广泛的光谱方法（包括 1-D-（（1）H 和（13）C）和 2-D-NMR 实验（CHcorr、HMBC、（1）H-（1）H COSY 和 NOESY）以及高分辨率 ES-MS）阐明了它们的结构，并发现它们在 DPPH 和 ABTS 测定中作为抗氧化剂具有相当高的活性。
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