Agaram R, Douglas M J, McTaggart R A, Gunka V
Department of Anesthesia, BC Women's Hospital, Vancouver BC, Canada.
Int J Obstet Anesth. 2009 Jan;18(1):10-4. doi: 10.1016/j.ijoa.2007.10.008. Epub 2008 Nov 28.
Labor epidural analgesia providing inadequate pain relief may cause maternal dissatisfaction and may fail to produce effective anesthesia when topped up for operative delivery. This study looked at factors associated with inadequate labor epidural analgesia.
Data were prospectively collected from 275 parturients receiving labor epidural analgesia. Pain was assessed 30 min after epidural insertion using a verbal pain scale of 0 to 100. A score of 10 or more was considered to represent inadequate pain relief. Sixteen factors chosen by experienced obstetric anesthesiologists for their association with inadequate labor epidural analgesia were studied.
Fifteen parturients were excluded. Forty-four of the remainder (16.9%) experienced inadequate pain relief. Multiparity, history of a previous failure of epidural analgesia, the use of air for loss of resistance, cervical dilatation >7 cm at insertion all had a statistically significant association with inadequate epidural analgesia (P<0.05). Logistic regression showed that cervical dilatation >7 cm, a history of opioid tolerance, a previous failed epidural and insertion of the epidural by a trainee anesthesiologist increased the odds ratio for inadequate pain relief.
The final model correctly classified 93% of the epidurals that provided effective analgesia but classified only 9.3% of those providing inadequate pain relief. This information can be used to develop a predictive score and change practice resulting in fewer inadequate epidurals.
分娩时硬膜外镇痛效果不佳可能导致产妇不满,且在剖宫产时追加药物后可能无法产生有效的麻醉效果。本研究探讨了与分娩时硬膜外镇痛效果不佳相关的因素。
前瞻性收集275例接受分娩硬膜外镇痛的产妇的数据。硬膜外穿刺30分钟后,使用0至100的语言疼痛量表评估疼痛程度。10分及以上的分数被认为代表镇痛效果不佳。研究了经验丰富的产科麻醉医生选择的16个与分娩硬膜外镇痛效果不佳相关的因素。
排除15例产妇。其余产妇中有44例(16.9%)镇痛效果不佳。经产妇、硬膜外镇痛既往失败史、使用空气确定阻力消失、穿刺时宫颈扩张>7cm均与硬膜外镇痛效果不佳有统计学显著相关性(P<0.05)。逻辑回归显示,宫颈扩张>7cm、阿片类药物耐受史、既往硬膜外镇痛失败以及由实习麻醉医生进行硬膜外穿刺会增加镇痛效果不佳的比值比。
最终模型正确分类了93%提供有效镇痛的硬膜外麻醉,但仅分类了9.3%镇痛效果不佳的硬膜外麻醉。这些信息可用于制定预测评分并改变实践,从而减少效果不佳的硬膜外麻醉情况。