对有鼻高反应性的女美发师进行过硫酸盐激发试验表明存在免疫细胞反应，但无IgE反应。
Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction.
作者信息
Diab Kerstin Kronholm, Truedsson Lennart, Albin Maria, Nielsen Jørn
机构信息
Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden.
出版信息
Int Arch Occup Environ Health. 2009 May;82(6):771-7. doi: 10.1007/s00420-008-0392-3. Epub 2008 Dec 2.
PURPOSE
The aim of this study was to examine the effects of persulphate on the nasal mucosa and on the immune cells in hairdressers suffering from bleaching powder associated rhinitis (BAR) versus subjects with rhinitis not previously exposed to bleaching powder.
METHODS
Fifteen hairdressers (S) with BAR, 14 without symptoms (WS) and 12 atopics (A) with rhinitis but without exposure to bleaching powder were studied. Each performed a nasal challenge with persulphates. Effect parameters were symptom score, acoustic rhinometry, albumin in nasal lavage, subpopulations of lymphocytes in blood and specific serum antibodies.
RESULTS
The S group had a post-challenge increase in nasal symptoms and nasal lavage albumin. The A group reacted to a lesser intent. The S and A groups showed an increase in Th1 cells. An HLA class II cell expression was noticed in both groups of hairdressers. No evidence of a type 1 reaction (immediate type) to persulphate was noticed.
CONCLUSIONS
Persulphate challenge affects hairdressers with BAR, but also atopics. The reaction may be driven by a Th1 cell activation.
目的
本研究旨在探讨过硫酸盐对患有漂粉相关鼻炎（BAR）的美发师鼻黏膜及免疫细胞的影响，并与未曾接触过漂粉的鼻炎患者进行对比。
方法
对15名患有BAR的美发师（S组）、14名无症状者（WS组）以及12名患有鼻炎但未接触过漂粉的特应性个体（A组）进行了研究。每位受试者均接受过硫酸盐的鼻腔激发试验。效应参数包括症状评分、鼻声反射测量、鼻腔灌洗中的白蛋白、血液中淋巴细胞亚群以及特异性血清抗体。
结果
S组在激发试验后鼻腔症状及鼻腔灌洗白蛋白增加。A组反应程度较轻。S组和A组Th1细胞均增加。两组美发师均观察到HLA II类细胞表达。未发现对过硫酸盐有1型反应（速发型）的证据。
结论
过硫酸盐激发试验对患有BAR的美发师有影响，对特应性个体也有影响。该反应可能由Th1细胞活化驱动。
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