Sampaio M, Serra V, Miro F, Calatayud C, Castellvi R M, Pellicer A
Department of Pediatrics, Valencia University School of Medicine, Spain.
Hum Reprod. 1991 Feb;6(2):194-7. doi: 10.1093/oxfordjournals.humrep.a137304.
The incidence of ovarian cyst formation during stimulation with additional pituitary suppression was retrospectively studied in 359 patients included in our in-vitro fertilization (IVF) programme. Women were classified according to the type of pituitary desensitization with subcutaneous buserelin used in group A (long protocol; n = 285) and group B (short protocol; n = 74). The rate of appearance of single follicular ovarian cysts for group A was 9.82% and for group B 22.97% (P less than 0.005). Ovarian cystic formations were usually asymptomatic and nonfunctional. The presence of these cysts did not seem to interfere with the ovarian response to stimulation treatment. Oocyte retrieval and pregnancy rate were similar between patients who developed ovarian cysts during gonadotrophin-releasing hormone analogue (GnRHa) therapy and those without cyst formation. These results suggest that ovarian cysts developing during GnRHa treatment are probably the consequence of the initial gonadotrophin rise and that the presence of ovarian cysts in these conditions should not be considered a necessary cause of cancellation for IVF patients.
我们对体外受精（IVF）项目中的359名患者进行了回顾性研究，以观察在额外垂体抑制刺激过程中卵巢囊肿形成的发生率。根据使用皮下布舍瑞林进行垂体脱敏的类型，将女性分为A组（长方案；n = 285）和B组（短方案；n = 74）。A组单卵泡卵巢囊肿的出现率为9.82%，B组为22.97%（P小于0.005）。卵巢囊性结构通常无症状且无功能。这些囊肿的存在似乎并未干扰卵巢对刺激治疗的反应。在促性腺激素释放激素类似物（GnRHa）治疗期间出现卵巢囊肿的患者与未形成囊肿的患者之间，卵母细胞取出率和妊娠率相似。这些结果表明，GnRHa治疗期间出现的卵巢囊肿可能是初始促性腺激素升高的结果，并且在这些情况下卵巢囊肿的存在不应被视为IVF患者取消治疗的必要原因。
