催化对映选择性分子间氢酰化反应：铑催化的β-S-醛与1,3-二取代丙二烯的反应
Catalytic enantioselective intermolecular hydroacylation: rhodium-catalyzed combination of beta-S-aldehydes and 1,3-disubstituted allenes.
作者信息
Osborne James D, Randell-Sly Helen E, Currie Gordon S, Cowley Andrew R, Willis Michael C
机构信息
Department of Chemistry, University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford, UK.
出版信息
J Am Chem Soc. 2008 Dec 24;130(51):17232-3. doi: 10.1021/ja8069133.
PMID:19053453
Abstract
A rhodium(I) catalyst incorporating the Me-DuPhos ligand promotes enantioselective intermolecular hydroacylation between beta-S-aldehydes and 1,3-disubstituted allenes. The nonconjugated enone products are obtained in good yields and with high enantioselectivities.
摘要
一种含有Me-DuPhos配体的铑（I）催化剂可促进β-S-醛与1,3-二取代丙二烯之间的对映选择性分子间氢酰化反应。非共轭烯酮产物的收率良好，对映选择性高。
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